Ischaemia Reperfusion Injury in Kidney Transplantation
نویسندگان
چکیده
The disruption of an organ’s blood supply is obligatory in clinical transplantation occurring at the time of organ procurement. During this ischaemic period complex pathophysiological changes occur within the organ that leave it primed in a pro-inflammatory state. Although the re-establishment of blood flow is essential to halt ongoing ischaemic damage, the organ incurs additional injury. This paradoxical response to reperfusion is known as ischaemia reperfusion injury (IRI).
منابع مشابه
The role of hormones in renal disease and ischemia-reperfusion injury
The patients with renal diseases, especially end-stage renal disease (ESRD), are at high risk of developing cardiovascular disturbances. Some hormones such as brain natriuretic peptide appear to be important serum biomarkers in predicting cardiac death in ESRD patients. Renal diseases cause inflammation, anemia, uremic toxins, fluid overload, and electrolyte disturbance. Kidney transplantation ...
متن کاملRemote ischaemic preconditioning by brief hind limb ischaemia protects against renal ischaemia-reperfusion injury: the role of adenosine.
BACKGROUND Remote ischaemic preconditioning (RIPC) is a strategy to protect a target organ against ischaemia-reperfusion injury (IRI) by inducing short-term ischaemia/reperfusion (I/R) in a remote organ. RIPC of the kidney by temporary limb occlusion would be a safe, inexpensive and noninvasive method to prevent renal damage in, e.g., transplantation and aortic surgery. We investigated whether ...
متن کاملAdministration of FR167653, a new anti-inflammatory compound, prevents renal ischaemia/reperfusion injury in mice.
BACKGROUND Various types of chemokines/cytokines play important roles in ischaemia/reperfusion injury in kidneys. However, the roles of p38 mitogen-activated protein kinase (MAPK) in the inflammatory processes of renal ischaemia/reperfusion injury remain to be investigated. We explored the effect of FR167653, a specific inhibitor of p38 MAPK, on renal ischaemia/reperfusion injury in mice. MET...
متن کاملRenal ischaemia reperfusion injury: a mouse model of injury and regeneration.
Renal ischaemia reperfusion injury (IRI) is a common cause of acute kidney injury (AKI) in patients and occlusion of renal blood flow is unavoidable during renal transplantation. Experimental models that accurately and reproducibly recapitulate renal IRI are crucial in dissecting the pathophysiology of AKI and the development of novel therapeutic agents. Presented here is a mouse model of renal...
متن کاملMesna: a novel renoprotective antioxidant in ischaemic acute renal failure.
BACKGROUND Reactive oxygen species (ROS) play a key role in renal ischaemia-reperfusion injury. After establishing the in vitro anti-oxidative potential of mesna, a sulfhydryl-containing compound, its effect on kidney function and morphology in a rat model of ischaemic acute renal failure (ARF) was examined. METHODS Mesna (180 mg/kg) was administered at different time points relative to ischa...
متن کامل